Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer.

@article{Zou2019GlutathioneSI,
  title={Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer.},
  author={Mingyue Zou and Xiaolei Hu and Bangtian Xu and Tingting Tong and Yixian Jing and Lei Xi and Wei Zhou and Jinpeng Lu and X. Wang and Xiaolan Yang and Fei Liao},
  journal={Oncology reports},
  year={2019},
  volume={41 2},
  pages={
          989-998
        }
}
The roles of glutathione S‑transferase pi 1 (GSTP1), glutathione S‑transferase mu 2 (GSTM2) and glutathione S‑transferase alpha 1 (GSTA1) in cisplatin (DDP)‑resistance of solid cancer cells (A549/DDP, SKOV3/DDP and SGC7901/DDP) were compared following expression downregulation with small interfering RNAs (siRNAs). DDP cytotoxicity was reflected by its half maximal inhibition concentration (IC50) calculated from data using a Cell Counting Kit‑8 assay; cell apoptosis was examined using flow… 

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