Glutathione Modulates Ca2+ Influx and Oxidative Toxicity Through TRPM2 Channel in Rat Dorsal Root Ganglion Neurons

@article{Nazrolu2011GlutathioneMC,
  title={Glutathione Modulates Ca2+ Influx and Oxidative Toxicity Through TRPM2 Channel in Rat Dorsal Root Ganglion Neurons},
  author={Mustafa Nazıroğlu and Cemil {\"O}zg{\"u}l and Bilal Çiğ and Salih Doğan and Abdulhadi Cihangir Uğuz},
  journal={The Journal of Membrane Biology},
  year={2011},
  volume={242},
  pages={109-118}
}
Glutathione (GSH) is the most abundant thiol antioxidant in mammalian cells and maintains thiol redox in the cells. GSH depletion has been implicated in the neurobiology of sensory neurons. Because the mechanisms that lead to melastatin-like transient receptor potential 2 (TRPM2) channel activation/inhibition in response to glutathione depletion and 2-aminoethyldiphenyl borinate (2-APB) administration are not understood, we tested the effects of 2-APB and GSH on oxidative stress and buthionine… CONTINUE READING

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