Glutathione Metabolism in Candida albicans Resistant Strains to Fluconazole and Micafungin

@inproceedings{Maras2014GlutathioneMI,
  title={Glutathione Metabolism in Candida albicans Resistant Strains to Fluconazole and Micafungin},
  author={Bruno Maras and Letizia Angiolella and Giuseppina Mignogna and Elisabetta Vavala and Alberto Macone and Marisa Colone and Giuseppina Pitari and Annarita Stringaro and Silvestro Dupr{\'e} and Anna Teresa Palamara},
  booktitle={PloS one},
  year={2014}
}
Currently available therapies for candidiasis are based on antifungal drugs belonging to azole and echinocandin families that interfere with different aspects of fungal metabolism. These drugs, beyond their specific effects, elicit also a cellular stress including an unbalance of redox state that is counteracted not only utilizing antioxidant species but also increasing the outcome export by transporters to detoxify the internal environment. These cellular actions are both based on the… CONTINUE READING
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