Glutathione Is an Endogenous Ligand of Rat Brain N-Methyl-D-Aspartate (NMDA) and 2-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionate (AMPA) Receptors

@article{Varga2004GlutathioneIA,
  title={Glutathione Is an Endogenous Ligand of Rat Brain N-Methyl-D-Aspartate (NMDA) and 2-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionate (AMPA) Receptors},
  author={V. Varga and Z. Jenei and R. Jan{\'a}ky and P. Saransaari and S. Oja},
  journal={Neurochemical Research},
  year={2004},
  volume={22},
  pages={1165-1171}
}
  • V. Varga, Z. Jenei, +2 authors S. Oja
  • Published 2004
  • Chemistry, Medicine
  • Neurochemical Research
  • A study was made of the effects of reduced (GSH) and oxidized (GSSG) glutathione on the Na+-independent and N-methyl-D-aspartate (NMDA) displaceable bindings of glutamate, on the binding of kainate, 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and ligands of the brain NMDA receptor-ionophore complex: glycine, dizocilpine (MK-801) and (±)-3-(2-car-boxypiperazin-4-yl)propyl-1-phosphonate (CPP). GSH and GSSG strongly inhibited the binding of glutamate, CPP and AMPA, kainate and glycine… CONTINUE READING
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