Glutathione – Responsive Polymeric Micelles Composed of In-Situ Formed Gemini Surfactants for Controlled Drug Release


SUMMARY We investigated the glutathione (GSH)dependent drug release behavior from the polymeric micelles of methoxypoly(ethylene glycol)-L-cysteine-poly(s-butyl cysteine) (mPEG-cys-PBC) that were oxidized in situ. The release rate of drug encapsulated in the polymeric micelles was increased with increasing GSH concentration, indicating that drug release can… (More)

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