Glutathione – Functions and Metabolism in the Malarial Parasite Plasmodium falciparum

@inproceedings{Becker2003GlutathioneF,
  title={Glutathione – Functions and Metabolism in the Malarial Parasite Plasmodium falciparum},
  author={Katja Becker and Stefan Rahlfs and Christine Nickel and R. Heiner Schirmer},
  booktitle={Biological chemistry},
  year={2003}
}
Abstract When present as a trophozoite in human erythrocytes, the malarial parasite Plasmodium falciparum exhibits an intense glutathione metabolism. Glutathione plays a role not only in antioxidative defense and in maintaining the reducing environment of the cytosol. Many of the known glutathione-dependent processes are directly related to the specific lifestyle of the parasite. Reduced glutathione (GSH) supports rapid cell growth by providing electrons for deoxyribonucleotide synthesis and it… 
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This review will highlight the mechanisms that are responsible for sustaining an adequate concentration of glutathione and maintaining its redox state in Plasmodium and discuss the potential of glutATHione metabolism for drug discovery against human malaria parasites.
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    Molecular microbiology
  • 2004
TLDR
In addition to these cytosolic redox systems the parasite also has an important mitochondrial antioxidant defence system and it is suggested that lipoic acid plays a pivotal part in defending the organelle from oxidative damage.
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It is demonstrated that de novo synthesis of GSH is pivotal for development of Plasmodium in the mosquito and the design of drugs aiming at interfering with the GSH redox-system in blood stages are flawed.
Thioredoxin networks in the malarial parasite Plasmodium falciparum.
TLDR
The present knowledge on the thioredoxin and peroxiredoxin metabolism in malaria parasitized red blood cells is summarized and novel data on the biochemical and kinetic characterization of differentThioredoxins, of AOP, and of the classic 1-Cys peroxIREDoxin of P. falciparum are reported.
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TLDR
In vitro data suggest that GR deficiency and drug-induced GR inhibition may protect from malaria by inducing enhanced ring stage phagocytosis rather than by impairing parasite growth directly.
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TLDR
The author used a new gene ontology technology to predict the molecular function and biological process in human and P. falciparum GR, which has similar molecular functions as gluthathione disulfide reductase activity, oxidoreductase activity and metal ion binding.
Purification and biochemical characterization of cytosolic glutathione-S-transferase from malarial parasites Plasmodium yoelii
TLDR
Kinetic studies on the purified GST enzyme revealed significant differences between the parasitic and mammalian enzymes, and Hemin, the known mammalian GST inhibitor was found to be a potent inhibitor of P. yoelii GST.
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