Glutathione: an overview of biosynthesis and modulation.

@article{Anderson1998GlutathioneAO,
  title={Glutathione: an overview of biosynthesis and modulation.},
  author={M. E. Anderson},
  journal={Chemico-biological interactions},
  year={1998},
  volume={111-112},
  pages={
          1-14
        }
}
  • M. Anderson
  • Published 1998
  • Chemistry, Medicine
  • Chemico-biological interactions
Glutathione (GSH; gamma-glutamylcysteinylglycine) is ubiquitous in mammalian and other living cells. It has several important functions, including protection against oxidative stress. It is synthesized from its constituent amino acids by the consecutive actions of gamma-glutamylcysteine synthetase and GSH synthetase. gamma-Glutamylcysteine synthetase activity is modulated by its light subunit and by feedback inhibition of the end product, GSH. Treatment with an inhibitor, buthionine sulfoximine… Expand
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TLDR
Different strategies for increasing GSH levels by supplying reversible bioconjugates able to cross the cellular membrane more easily than GSH and to provide a source of thiols for GSH synthesis are discussed. Expand
The Glutathione Pathway
T he tripeptide glutathione (GSH) is nearly ubiquitous in cells and has been shown to participate in a multitude of cellular functions (Kosower and Kosower, 1978; Reed and Fariss, 1984; Reed, 1990;Expand
The Glutathione Pathway
T he tripeptide glutathione (GSH) is nearly ubiquitous in cells and has been shown to participate in a multitude of cellular functions (Kosower and Kosower, 1978; Reed and Fariss, 1984; Reed, 1990;Expand
The Glutathione Pathway
T he tripeptide glutathione (GSH) is nearly ubiquitous in cells and has been shown to participate in a multitude of cellular functions (Kosower and Kosower, 1978; Reed and Fariss, 1984; Reed, 1990;Expand
The Glutathione Pathway
T he tripeptide glutathione (GSH) is nearly ubiquitous in cells and has been shown to participate in a multitude of cellular functions (Kosower and Kosower, 1978; Reed and Fariss, 1984; Reed, 1990;Expand
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TLDR
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