Glutathione, oxidative stress and neurodegeneration.

  title={Glutathione, oxidative stress and neurodegeneration.},
  author={J{\"o}rg Bernhard Schulz and Joerg Lindenau and Jan Seyfried and Johannes Dichgans},
  journal={European journal of biochemistry},
  volume={267 16},
There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species and mitochondrial dysfunction. Here, we review the evidence for a disturbance of glutathione homeostasis that may either lead to or result from oxidative stress in neurodegenerative disorders. Glutathione is an important intracellular antioxidant… CONTINUE READING
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