Glutaric acid moderately compromises energy metabolism in rat brain.

  title={Glutaric acid moderately compromises energy metabolism in rat brain.},
  author={Gustavo da C Ferreira and Carolina Maso Viegas and Patr{\'i}cia Fernanda Schuck and Alexandra Latini and Carlos Severo Dutra-Filho and Angela Terezinha de Souza Wyse and Cl{\'o}vis Milton Duval Wannmacher and Carmen Regla Vargas and Moacir Wajner},
  journal={International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  volume={23 8},
Glutaric acidemia type I is an inherited metabolic disorder biochemically characterized by tissue accumulation of predominantly glutaric acid (GA). Affected patients present frontotemporal hypotrophy, as well as caudate and putamen injury following acute encephalopathic crises. Considering that the underlying mechanisms of basal ganglia damage in this disorder are poorly known, in the present study we tested the effects of glutaric acid (0.2-5mM) on critical enzyme activities of energy… CONTINUE READING