Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae.

@article{PujolCarrion2006GlutaredoxinsGA,
  title={Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae.},
  author={Nuria Pujol-Carrion and Gemma Bell{\'i} and Enrique Montero Herrero and Antoni Nogu{\'e}s and Maria Angeles de la Torre-Ruiz},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 21},
  pages={4554-64}
}
Grx3 and Grx4, two monothiol glutaredoxins of Saccharomyces cerevisiae, regulate Aft1 nuclear localisation. We provide evidence of a negative regulation of Aft1 activity by Grx3 and Grx4. The Grx domain of both proteins played an important role in Aft1 translocation to the cytoplasm. This function was not, however, dependent on the availability of iron… CONTINUE READING