Glutaredoxin2 isoform b (Glrx2b) promotes RANKL-induced osteoclastogenesis through activation of the p38-MAPK signaling pathway.

@article{Yeon2012Glutaredoxin2IB,
  title={Glutaredoxin2 isoform b (Glrx2b) promotes RANKL-induced osteoclastogenesis through activation of the p38-MAPK signaling pathway.},
  author={Jeong-Tae Yeon and Sik-Won Choi and Kie-In Park and Min-Kyu Choi and Jeong-joong Kim and Byung-Soo Youn and Myeung Su Lee and Jaemin Oh},
  journal={BMB reports},
  year={2012},
  volume={45 3},
  pages={
          171-6
        }
}
Receptor activator of NF-κB ligand (RANKL) triggers the differentiation of bone marrow-derived monocyte/macrophage precursor cells (BMMs) of hematopoietic origin into osteoclasts through the activation of mitogen-activated protein (MAP) kinases and transcription factors. Recently, reactive oxygen species (ROS) and antioxidant enzymes were shown to be closely associated with RANKL-mediated osteoclast differentiation. Although glutaredoxin2 (Glrx2) plays a role in cellular redox homeostasis, its… CONTINUE READING

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