Glutaredoxin1 protects neuronal cells from copper-induced toxicity

  title={Glutaredoxin1 protects neuronal cells from copper-induced toxicity},
  author={Michael A. Cater and Stephanie Materia and Zhiguang Xiao and Kamil Wolyniec and Susan M. Ackland and Yann Wan Yap and Nam Sang Cheung and Sharon La Fontaine},
Glutaredoxin1 (GRX1) is a glutathione (GSH)-dependent thiol oxidoreductase. The GRX1/GSH system is important for the protection of proteins from oxidative damage and in the regulation of protein function. Previously we demonstrated that GRX1/GSH regulates the activity of the essential copper-transporting P1B-Type ATPases (ATP7A, ATP7B) in a copper-responsive manner. It has also been established that GRX1 binds copper with high affinity and regulates the redox chemistry of the metallochaperone… CONTINUE READING


Publications citing this paper.
Showing 1-8 of 8 extracted citations

Glutaredoxin Desensitizes Lens to Oxidative Stress by Connecting and Integrating Specific Signaling and Transcriptional Regulation for Antioxidant Response.

Qi Fan, Y Zhang, +7 authors Yi Lu
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2016


Publications referenced by this paper.
Showing 1-10 of 41 references

Glutaredoxins in thiol/disulfide exchange.

Antioxidants & redox signaling • 2013
View 2 Excerpts
Highly Influenced

Protein-thiol oxidation and cell death: regulatory role of glutaredoxins.

Antioxidants & redox signaling • 2012
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…