Glutaredoxin1 protects neuronal cells from copper-induced toxicity

@article{Cater2014Glutaredoxin1PN,
  title={Glutaredoxin1 protects neuronal cells from copper-induced toxicity},
  author={Michael A. Cater and Stephanie Materia and Zhiguang Xiao and Kamil Wolyniec and Susan M. Ackland and Yann Wan Yap and Nam Sang Cheung and Sharon La Fontaine},
  journal={BioMetals},
  year={2014},
  volume={27},
  pages={661-672}
}
Glutaredoxin1 (GRX1) is a glutathione (GSH)-dependent thiol oxidoreductase. The GRX1/GSH system is important for the protection of proteins from oxidative damage and in the regulation of protein function. Previously we demonstrated that GRX1/GSH regulates the activity of the essential copper-transporting P1B-Type ATPases (ATP7A, ATP7B) in a copper-responsive manner. It has also been established that GRX1 binds copper with high affinity and regulates the redox chemistry of the metallochaperone… CONTINUE READING

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