Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1.

Abstract

Embryonic development depends on complex and precisely orchestrated signaling pathways including specific reduction/oxidation cascades. Oxidoreductases of the thioredoxin family are key players conveying redox signals through reversible posttranslational modifications of protein thiols. The importance of this protein family during embryogenesis has recently… (More)
DOI: 10.1073/pnas.1313753110

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