Glutaraldehyde-treated bovine pericardium: effects of lyophilization on cytotoxicity and residual aldehydes.

  title={Glutaraldehyde-treated bovine pericardium: effects of lyophilization on cytotoxicity and residual aldehydes.},
  author={Marina Junko Shiotsu Maizato and Olga Zazuco Higa and M{\^o}nica Beatriz Mathor and Maria Aparecida Pires Camillo and Patric J Spencer and Ronaldo de Nogueira Moraes Pitombo and Cec{\'i}lia Am{\'e}lia de Carvalho Zavaglia and Adolfo A. Leirner},
  journal={Artificial organs},
  volume={27 8},
This work assesses the effect of lyophilization on the cytotoxicity and residual aldehyde concentration of glutaraldehyde-treated and lyophilized bovine pericardium (group A), comparing it to conventional glutaraldehyde-treated bovine pericardium (group B). Cytotoxicity was measured by incubating a pericardium sample from each group in saline and assessing the eluant's influence on cellular growth. Residual aldehydes were measured by HPLC. Although both groups' eluants exhibited some… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 14 extracted citations


Publications referenced by this paper.
Showing 1-10 of 17 references

Bovine pericardium (BP): effect of lyophilization on mechanical properties, shrinkage temperature and cytotoxicity [abstract

  • AA Leirner, MJS Maizato, +4 authors CAC. Zavaglia
  • ASAIO J 2002;48:193
  • 2003
1 Excerpt

Influence of different chemical crosslinking treatments on the properties of bovine pericardium and collagen

  • EJ Herrero, P Fernández, +5 authors JLC. Olivares
  • Biomaterials
  • 1999
1 Excerpt

A practical guide to ISO 10993-5: Cytotoxicity

  • RF Wallin, EF Arscott
  • Medical Device link. April
  • 1998
1 Excerpt

Wolner E. Acid glycoproteins accumulate in calcified areas of bioprosthetic tissue

  • M Grabenwöger, P Böck, +4 authors H Bergmeister
  • J Heart Valves Dis 1998;7:229–34
  • 1998
1 Excerpt

A critical review of the toxicology of glutaraldehyde

  • RO Beauchamp, MB St. Clair, TR Fennell, DO Clarke, KL. Morgan
  • Crit Rev Toxicol 1992;22:143–74
  • 1992
2 Excerpts

Similar Papers

Loading similar papers…