Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila.

@article{Wloga2008GlutamylationOA,
  title={Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila.},
  author={Dorota Wloga and Krzysztof Rogowski and Neeraj Sharma and Juliette Van Dijk and Carsten Janke and Bernard Edd{\'e} and M. -H. Br{\'e} and Nicolette Levilliers and Virginie Redeker and Jianming Duan and M. A. Gorovsky and Maria Jerka-Dziadosz and Jacek Gaertig},
  journal={Eukaryotic cell},
  year={2008},
  volume={7 8},
  pages={1362-72}
}
Tubulin undergoes glutamylation, a conserved posttranslational modification of poorly understood function. We show here that in the ciliate Tetrahymena, most of the microtubule arrays contain glutamylated tubulin. However, the length of the polyglutamyl side chain is spatially regulated, with the longest side chains present on ciliary and basal body microtubules. We focused our efforts on the function of glutamylation on the alpha-tubulin subunit. By site-directed mutagenesis, we show that all… CONTINUE READING

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