Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution

@inproceedings{Schilling2008GlutaminylCF,
  title={Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution},
  author={Stephan Schilling and Claus Wasternack and Hans-Ulrich Demuth},
  booktitle={Biological chemistry},
  year={2008}
}
Abstract Several mammalian peptide hormones and proteins from plant and animal origin contain an N-terminal pyroglutamic acid (pGlu) residue. Frequently, the moiety is important in exerting biological function in either mediating interaction with receptors or stabilizing against N-terminal degradation. Glutaminyl cyclases (QCs) were isolated from different plants and animals catalyzing pGlu formation. The recent resolution of the 3D structures of Carica papaya and human QCs clearly supports… Expand
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TLDR
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TLDR
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TLDR
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TLDR
PQC, a 33 kDa enzyme found in the latex of the tropical tree Carica papaya, displays an exceptional resistance to chemical and thermal denaturation as well as to proteolysis, and was isolated from papaya latex, purified and crystallized by the hanging-drop vapour-diffusion method. Expand
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TLDR
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