Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.

@article{Gallipoli2018GlutaminolysisIA,
  title={Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.},
  author={Paolo Gallipoli and George Giotopoulos and Konstantinos Tzelepis and Ana S. H. Costa and Shabana Vohra and Paula Medina-P{\'e}rez and Faisal T M Basheer and Ludovica Marando and Lorena Di Lisio and Jo{\~a}o M. L. Dias and Haiyang Yun and Daniel Sasca and Sarah J. Horton and George S Vassiliou and Christian Frezza and Brian J P Huntly},
  journal={Blood},
  year={2018},
  volume={131 15},
  pages={
          1639-1653
        }
}
FLT3 internal tandem duplication (FLT3ITD) mutations are common in acute myeloid leukemia (AML) associated with poor patient prognosis. Although new-generation FLT3 tyrosine kinase inhibitors (TKI) have shown promising results, the outcome of FLT3ITD AML patients remains poor and demands the identification of novel, specific, and validated therapeutic… CONTINUE READING