Glutamine synthetase induced spinal seizures in rats.

  title={Glutamine synthetase induced spinal seizures in rats.},
  author={D. W. Shin and Young Sul Yoon and Masato Matsumoto and Wencheng Huang and Phil Ceraulo and Wise Young},
  journal={Yonsei medical journal},
  volume={44 1},
Glutamine synthetase (GS) is a key enzyme in the regulation of glutamate neurotransmission in the central nervous system. It is responsible for converting glutamate to glutamine, consuming one ATP and NH3 in the process. Glutamate is neurotoxic when it accumulates in extracellular fluids. We investigated the effects of GS in both a spinal cord injury (SCI) model and normal rats. 0.1-ml of low (2- micro M) and high (55- micro M) concentrations of GS were applied, intrathecally, to the spinal… CONTINUE READING