Glutamine synthetase in cerebrospinal fluid, serum, and brain: a diagnostic marker for Alzheimer disease?

@article{Tumani1999GlutamineSI,
  title={Glutamine synthetase in cerebrospinal fluid, serum, and brain: a diagnostic marker for Alzheimer disease?},
  author={Hayrettin Tumani and G Q Shen and James B. Peter and Wolfgang Br{\"u}ck},
  journal={Archives of neurology},
  year={1999},
  volume={56 10},
  pages={1241-6}
}
OBJECTIVES To determine whether the glutamine synthetase (GS) level in cerebrospinal fluid (CSF) is a useful biochemical marker in the diagnosis of Alzheimer disease (AD), and to assess the source of GS (brain vs. blood derived) in CSF. METHODS Sandwich enzyme immunoassay and immunoblotting were applied to detect GS in CSF and in serum from neurologically healthy control subjects and patients with neurodegenerative diseases, including AD. The origin of GS was estimated by the concentration… CONTINUE READING

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