Glutamine synthetase: a key enzyme for intestinal epithelial differentiation?

  title={Glutamine synthetase: a key enzyme for intestinal epithelial differentiation?},
  author={Michael D. Weiss and Vincent G DeMarco and Daniel M Strauss and Don Samuelson and Majella Lane and Josef Neu},
  journal={JPEN. Journal of parenteral and enteral nutrition},
  volume={23 3},
BACKGROUND We have previously shown that glutamine synthetase protein and mRNA are concentrated in the crypt region of the rat small intestine and that the activity of this enzyme is highest around the time of weaning. This anatomical location and time of peak activity are sites and periods of active enterocyte differentiation. This led to our current hypothesis that glutamine synthetase is important in the differentiation of enterocytes. METHODS To test our hypothesis, we treated Caco-2… CONTINUE READING


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