Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis

@article{Ferreira2020GlutamineSI,
  title={Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis},
  author={C. Ferreira and I. Mesquita and A. M. Barbosa and N. Os{\'o}rio and E. Torrado and C. Beauparlant and A. Droit and C. Cunha and A. Carvalho and B. Saha and J. Estaquier and Ricardo Silvestre},
  journal={PLoS Neglected Tropical Diseases},
  year={2020},
  volume={14}
}
Background The disturbance of host metabolic pathways by Leishmania parasites has crucial consequences for the activation status of immune cells and the outcome of infection. Glutamine has been described as an immunomodulatory amino acid, yet its role during Leishmania infection is still unknown. Methods We performed transcriptomics in uninfected and L. donovani-infected macrophages 6 hours post-infection. Glutamine quantification by HPLC was assessed in the supernatant of macrophages… Expand
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