Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.

@article{Timmerman2013GlutamineSA,
  title={Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.},
  author={Luika A. Timmerman and Thomas Holton and Mariia Yuneva and Raymond J. Louie and Merc{\`e} Padr{\'o} and Anneleen Daemen and Min Hu and Denise A. Chan and Stephen P Ethier and Laura J van 't Veer and Korn{\'e}lia Poly{\'a}k and Frank Mccormick and Joe W. Gray},
  journal={Cancer cell},
  year={2013},
  volume={24 4},
  pages={450-65}
}
A handful of tumor-derived cell lines form the mainstay of cancer therapeutic development, yielding drugs with an impact typically measured as months to disease progression. To develop more effective breast cancer therapeutics and more readily understand their clinical impact, we constructed a functional metabolic portrait of 46 independently derived breast cell lines. Our analysis of glutamine uptake and dependence identified a subset of triple-negative samples that are glutamine auxotrophs… CONTINUE READING
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