Glutamine repeats and inherited neurodegenerative diseases: molecular aspects.

@article{Perutz1996GlutamineRA,
  title={Glutamine repeats and inherited neurodegenerative diseases: molecular aspects.},
  author={Max F. Perutz},
  journal={Current opinion in structural biology},
  year={1996},
  volume={6 6},
  pages={848-58}
}
  • Max F. Perutz
  • Published 1996 in Current opinion in structural biology
Several dominantly inherited, late onset, neurodegenerative diseases are due to expansion of CAG repeats, leading to expansion of glutamine repeats in the affected proteins. These proteins are of very different sizes and, with one exception, show no sequence homology to known proteins or to each other; their functions are unknown. In some, the glutamine… CONTINUE READING