Glutamine prevents fibrosis development in rats with colitis induced by 2,4,6-trinitrobenzene sulfonic acid.

@article{SanMiguel2010GlutaminePF,
  title={Glutamine prevents fibrosis development in rats with colitis induced by 2,4,6-trinitrobenzene sulfonic acid.},
  author={Beatriz San-Miguel and Irene Crespo and N{\'e}lson Alexandre Kretzmann and Jos{\'e} Lu{\'i}s Mauriz and N. Marroni and Mar{\'i}a Jes{\'u}s Tu{\~n}{\'o}n and Javier Gonz{\'a}lez-Gallego},
  journal={The Journal of nutrition},
  year={2010},
  volume={140 6},
  pages={1065-71}
}
We investigated the effects of glutamine on the development of colonic fibrosis and on the expression of the major fibrogenic factors in a rat model of experimental colitis. Colitis was induced in one-half of the male Wistar rats by intracolonic administration of 30 mg of 2,4,6-trinitrobenzene sulfonic acid (TNBS). L-glutamine (25 mg/kg) was administered rectally to one-half of the controls and one-half of the colitic rats. The control, control+glutamine, TNBS, and TNBS+glutamine groups were… CONTINUE READING