Glutamine preserves protein synthesis and paracellular permeability in Caco-2 cells submitted to "luminal fasting".

@article{Bacquer2003GlutaminePP,
  title={Glutamine preserves protein synthesis and paracellular permeability in Caco-2 cells submitted to "luminal fasting".},
  author={Olivier Le Bacquer and Christian L. Laboisse and Dominique H Darmaun},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={285 1},
  pages={G128-36}
}
This study used polarized cell line Caco-2 as a model of human enterocytes to determine: 1) whether deprivation of nutrients on the apical (luminal) side of the epithelium (fasting) alters protein synthesis in enterocytes; 2) if so, whether glutamine can attenuate the effects of fasting; and 3) whether the effects of glutamine depend on its route (i.e., apical vs. basolateral) of supply. Caco-2 cells were submitted to nutrient deprivation on the apical side to mimic the effects of fasting… CONTINUE READING

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