Glutamine potentiates TNF-alpha-induced tumor cytotoxicity.

  title={Glutamine potentiates TNF-alpha-induced tumor cytotoxicity.},
  author={Elena Obrador and Juli{\'a}n Carretero and Juan Miguel Esteve and Jos{\'e} Antonio Pellicer and Angel Pascual and Ignacio Petschen and Jos{\'e} M Estrela},
  journal={Free radical biology & medicine},
  volume={31 5},
L-glutamine (Gln) sensitizes tumor cells to tumor necrosis factor (TNF)-alpha-induced cytotoxicity. The type and mechanism of cell death induced by TNF-alpha was studied in Ehrlich ascites tumor (EAT)-bearing mice fed a Gln-enriched diet (GED; where 30% of the total dietary nitrogen was from Gln). A high rate of Gln oxidation promotes a selective depletion of mitochondrial glutathione (mtGSH) content to approximately 58% of the level found in tumor mitochondria of mice fed a nutritionally… CONTINUE READING


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