Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

@article{Yang2014GlutamineOM,
  title={Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.},
  author={Chendong Yang and Bookyung Ko and Christopher T. Hensley and Lei Jiang and Ajla T. Wasti and Jiyeon Kim and Jessica A. Sudderth and Maria Antonietta Calvaruso and Lloyd Lumata and Matthew A. Mitsche and Jared Rutter and Matthew E Merritt and Ralph J DeBerardinis},
  journal={Molecular cell},
  year={2014},
  volume={56 3},
  pages={414-24}
}
Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these compensatory pathways may produce synthetic lethality. We previously demonstrated that glucose deprivation stimulated a pathway in which acetyl-CoA was formed from glutamine downstream of glutamate dehydrogenase (GDH). Here we show that import of pyruvate into the mitochondria suppresses GDH and glutamine-dependent acetyl-CoA formation. Inhibiting the mitochondrial pyruvate carrier (MPC) activates GDH and… CONTINUE READING
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Lactate , pyruvate and ketone bodies

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Highly Influential
1 Excerpt

Lactate, pyruvate and ketone bodies. In Techniques in diagnostic human biochemical genetics, E.A

  • A. Vassault, J. P. Bonnefont, N. Specola, J. M. Saudubray
  • 1991
Highly Influential
2 Excerpts

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

  • Yang
  • Molecular Cell (2014),
  • 2014
2 Excerpts

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