Glutamine metabolism in endothelial cells: ornithine synthesis from glutamine via pyrroline-5-carboxylate synthase.

@article{Wu2000GlutamineMI,
  title={Glutamine metabolism in endothelial cells: ornithine synthesis from glutamine via pyrroline-5-carboxylate synthase.},
  author={Guoyao Wu and Tony E. Haynes and Hongbing Li and Cynthia Meininger},
  journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology},
  year={2000},
  volume={126 1},
  pages={115-23}
}
L-Glutamine (the most abundant free amino acid in plasma and the body) is a potent inhibitor of endothelial NO synthesis. However, little is known about glutamine metabolism in endothelial cells (EC). As an initial step toward understanding the role of glutamine in endothelial physiology, the present study was conducted to quantify glutamine catabolism in microvascular, aortic and venous EC. For metabolic studies, EC were incubated for 1 h in Krebs bicarbonate buffer containing 5 mM glucose and… CONTINUE READING

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