Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis

@article{Hilgier2009GlutamineIA,
  title={Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis},
  author={W. Hilgier and I. Frȩśko and Emilia Klemenska and A. Berȩsewicz and S. Oja and P. Saransaari and J. Albrecht and M. Zielińska},
  journal={Neurobiology of Disease},
  year={2009},
  volume={35},
  pages={75-81}
}
Brain L-glutamine (Gln) accumulation and increased activity of the NO/cGMP pathway are immediate consequences of acute exposure to ammonia. This study tested whether excess Gln may influence NO and/or cGMP synthesis. Intrastriatal administration of the glutaminase inhibitor 6-diazo-5-oxo-L-norleucine or the system A-specific Gln uptake inhibitor methylaminoisobutyrate increased microdialysate Gln concentration and reduced basal and ammonia-induced NO and cGMP accumulation. Gln applied in vivo… Expand
Roles of glutamine in neurotransmission.
Glutamine as a mediator of ammonia neurotoxicity: A critical appraisal.
Exchange-mode glutamine transport across CNS cell membranes
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