Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1.

@article{Singleton2008GlutamineIH,
  title={Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1.},
  author={K. Singleton and P. Wischmeyer},
  journal={JPEN. Journal of parenteral and enteral nutrition},
  year={2008},
  volume={32 4},
  pages={
          371-6
        }
}
  • K. Singleton, P. Wischmeyer
  • Published 2008
  • Medicine
  • JPEN. Journal of parenteral and enteral nutrition
  • BACKGROUND Glutamine (GLN) improves outcome in experimental and clinical states of illness and injury. The authors hypothesized GLN-mediated enhancement of O-glycosylation and subsequent phosphorylation of key transcription factors in the HSP70 pathway would lead to increased HSP70 expression following experimental sepsis. METHODS Mice underwent cecal ligation and puncture (CLP)-induced sepsis and were treated with GLN (0.75 g/kg) or a saline placebo 30 minutes after CLP. A separate group of… CONTINUE READING

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