Glutamine induces heat-shock protein-70 and glutathione expression and attenuates ischemic damage in rat islets.

@article{Jang2008GlutamineIH,
  title={Glutamine induces heat-shock protein-70 and glutathione expression and attenuates ischemic damage in rat islets.},
  author={H J Jang and Jung Hyun Kwak and Eun Young Cho and Y M We and Yie Hou Lee and S C Kim and Duck Jong Han},
  journal={Transplantation proceedings},
  year={2008},
  volume={40 8},
  pages={2581-4}
}
BACKGROUND The transplantation of isolated islets is believed to be an attractive approach for cure of diabetes mellitus. Heat-shock protein (HSP70), which plays a vital role in cellular protection, has been detected in various tissues subjected to stress. Glutamine (GLN) is an important cellular fuel and an essential precursor for the antioxidant glutathione (GSH). It is believed to enhance cellular survival against a variety of stressful stimuli through HSP70. Thus, we performed this study to… CONTINUE READING

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