Glutamine in the central nervous system: function and dysfunction.

  title={Glutamine in the central nervous system: function and dysfunction.},
  author={Jan Albrecht and Ursula Sonnewald and Helle S{\o}nderby Waagepetersen and Arne Schousboe},
  journal={Frontiers in bioscience : a journal and virtual library},
Glutamine (Gln) abounds in the central nervous system (CNS), and its interstitial and cerebrospinal fluid (CSF) concentrations are at least one order of magnitude higher than of any other amino acid. Gln transport from blood to the brain is insufficient to meet the demand of the brain tissues for this amino acid. This demand is met by intracerebral Gln synthesis from glutamate (Glu), a reaction carried out by glutamine synthetase (GS), an enzyme residing in astrocytes. A major proportion of… 

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