Glutamine facilitates chemotherapy while reducing toxicity.

@article{Klimberg1992GlutamineFC,
  title={Glutamine facilitates chemotherapy while reducing toxicity.},
  author={V S Klimberg and Emmanuel Nwokedi and Laura F Hutchins and A. A. Pappas and Nicholas P. Lang and John R. Broadwater and Raymond C. Read and Kent C. Westbrook},
  journal={JPEN. Journal of parenteral and enteral nutrition},
  year={1992},
  volume={16 6 Suppl},
  pages={
          83S-87S
        }
}
Dose intensification of chemotherapy is thought to increase survival. With recent advances in hemopoietic cell modulators such as granulocyte colony stimulating factor, the limiting toxicity of intensifying chemotherapeutic regimens has become the severity of the associated enterocolitis. In animal models, glutamine protects the host from methotrexate-induced enterocolitis. This study evaluates the effects of a glutamine-supplemented diet on the tumoricidal effectiveness of methotrexate… Expand
Effect of glutamine on methotrexate efficacy and toxicity.
TLDR
These studies suggest that GLN supplementation is safe in its administration to the tumor-bearing host receiving MTX, and may serve to increase the therapeutic window of this chemotherapeutic age. Expand
Glutamine: A novel approach to chemotherapy-induced toxicity
  • K. Gaurav, R. Goel, M. Shukla, M. Pandey
  • Medicine
  • Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
  • 2012
TLDR
Current data supports the usefulness of glutamine supplementation in reducing complications of chemotherapy; however, paucity of clinical trials weakens the clear interpretation of these findings. Expand
Prevention of chemotherapy and radiation toxicity with glutamine.
TLDR
The available evidence suggests that glutamine supplementation may decrease the incidence and/or severity of chemotherapy-associated mucositis, irinotecan-associated diarrhea, paclitaxel-induced neuropathy, hepatic veno-occlusive disease in the setting of high dose chemotherapy and stem cell transplantation, and the cardiotoxicity that accompanies anthracycline use. Expand
Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study.
TLDR
In conclusion, glutamine did not prevent the occurrence of the doxifluridine-induced diarrhea and did not have any impact on tumor response to chemotherapy. Expand
Glutamine Enhances Immunoregulation of Tumor Growth
TLDR
This study evaluated the effects of oral Gln on Gln and glutathione metabolism, NK cell activity, and tumor growth in the tumor-bearing rat. Expand
Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model.
TLDR
Glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model, and IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in5-FU group. Expand
Glutamine, cancer, and its therapy*
TLDR
A large body of evidence in vivo suggests that supplemental glutamine does not make tumors grow but in fact results in decreased growth through stimulation of the immune system, when given with radiation or chemotherapy, glutamine protects the host and actually increases the selectivity of therapy for the tumor. Expand
Glutamine as indispensable nutrient in oncology: experimental and clinical evidence
TLDR
In various clinical situations, appropriate exogenous glutamine supply is safe and can beneficially contribute to diminish risks of high-dose chemotherapy and radiation and to retard severe complications such as multi-organ failure. Expand
Chemotherapy Does Not Influence Intestinal Amino Acid Uptake in Children
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Most children receiving chemotherapy are already catabolic before start of a new cycle of chemotherapy, and Amino acid transport as measured by leucine uptake in the intestine is not affected by chemotherapy-induced mucositis. Expand
Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy
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Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients, and topical and oral glutamine seem to be the preferred routes for this amino acid to promote mucosal healing during and after cancer treatment. Expand
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In this tumor model, TPN + GLN does not appear to increase tumor size, tumor DNA content, or tumor glutamine metabolism, but the ratio of tumor cells to host infiltrating cells within the tumor mass, appears to be increased. Expand
Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation.
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It is demonstrated that provision of oral glutamine after abdominal radiation supported gut glutamine metabolism, improved mucosal morphometrics, and decreased the morbidity and mortality associated with this abdominal radiation model. Expand
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TLDR
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TLDR
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TLDR
Experimental evidence is presented indicating a very good correlation between the activity of mitochondrial glutaminase and the rate of respiration of tumor mitochondria in the presence of glutamine, one of the most important substrates in the oxidative and energy metabolism of rapidly growing malignant cells in vivo. Expand
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TLDR
The data indicate that metabolism of glutamine to glutamate occurs in mitochondria of both villus and crypt cells and that phosphate-dependent glutaminase is the major glutamine-utilizing enzyme of small intestine. Expand
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TLDR
Current parenteral formulation may not provide appropriate fuels for the gastrointestinal tract in patients with gastrointestinal disorders, because circulating levels of beta-hydroxybutyrate and glutamines are often low, and glutamine is absent from standard amino acid solutions. Expand
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