Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium.

@article{Motoki2011GlutamineDI,
  title={Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium.},
  author={Takayuki Motoki and Y. Naomoto and J. Hoshiba and Y. Shirakawa and T. Yamatsuji and J. Matsuoka and M. Takaoka and Y. Tomono and Y. Fujiwara and H. Tsuchita and M. Gunduz and H. Nagatsuka and N. Tanaka and T. Fujiwara},
  journal={World journal of gastroenterology},
  year={2011},
  volume={17 6},
  pages={
          717-26
        }
}
AIM To investigate the possible biological outcome and effect of glutamine depletion in neonatal mice and rodent intestinal epithelial cells. METHODS We developed three kinds of artificial milk with different amounts of glutamine; Complete amino acid milk (CAM), which is based on maternal mouse milk, glutamine-depleted milk (GDM), and glutamine-rich milk (GRM). GRM contains three-fold more glutamine than CAM. Eighty-seven newborn mice were divided into three groups and were fed with either of… Expand