Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

@article{Klysz2015GlutaminedependentP,
  title={Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation},
  author={Dorota Klysz and Xuguang Tai and Philippe A. Robert and Marco Craveiro and Gaspard Cretenet and Leal Oburoglu and C{\'e}dric Mongellaz and Stefan Floess and Vanessa Fritz and Maria I Matias and Carmen S.M. Yong and Natalie Surh and Julien C. Marie and Jochen Huehn and Val{\'e}rie S. Zimmermann and Sandrina Kinet and Val{\'e}rie A Dardalhon and Naomi Taylor},
  journal={Science Signaling},
  year={2015},
  volume={8},
  pages={ra97-ra97}
}
T cell activation requires that the cell meet increased energetic and biosynthetic demands. We showed that exogenous nutrient availability regulated the differentiation of naïve CD4+ T cells into distinct subsets. Activation of naïve CD4+ T cells under conditions of glutamine deprivation resulted in their differentiation into Foxp3+ (forkhead box P3–positive) regulatory T (Treg) cells, which had suppressor function in vivo. Moreover, glutamine-deprived CD4+ T cells that were activated in the… CONTINUE READING
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A.Cantrell, Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

  • L.V.Sinclair, J. Rolf, E. Emslie, Y.-B. Shi, D.P.M. Taylor
  • Nat. Immunol
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1 Excerpt

Control of amino - acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

  • J. Rolf, E. Emslie, Y.-B. Shi, P. M. Taylor, D. A. Cantrell
  • Nat . Immunol .
  • 2013

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