Glutamine decreases lipopolysaccharide-induced intestinal inflammation in infant rats.

@article{Li2004GlutamineDL,
  title={Glutamine decreases lipopolysaccharide-induced intestinal inflammation in infant rats.},
  author={Nan Li and Kellym Liboni and Mao Zhong Fang and Don A. Samuelson and P. A. Lewis and Roshan Patel and Josef Neu},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2004},
  volume={286 6},
  pages={
          G914-21
        }
}
  • N. Li, Kellym Liboni, +4 authors J. Neu
  • Published 1 June 2004
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
Using a gastrostomy-fed (GF) rat infant "pup-in-a-cup" model, the effects of protein deprivation and supplemental glutamine (Gln) and glutamate (Glu) were examined to test the hypothesis that Gln decreases the proinflammatory response induced by LPS in the developing infant rat small intestine. Four groups of 6- to 7-day-old pups were fed a rat milk substitute (RMS), one providing 100% and three providing 25% of normal protein intake for another 6 days. Two of the 25% protein-fed groups… 
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63 Citations
Highly Influential Citations
3
Background Citations
21
Methods Citations
2
Results Citations
1

63 Citations

Citation Type

Citation Type

Lactobacillus rhamnosus GG Decreases Lipopolysaccharide-induced Systemic Inflammation in a Gastrostomy-fed Infant Rat Model
  • Liyan Zhang, N. Li, +5 authors J. Neu
  • Medicine, Biology
    Journal of pediatric gastroenterology and nutrition
  • 2006
TLDR
LGG provided by the enteral route is able to downregulate LPS-induced proinflammatory mediators, and extends to the plasma and a distal organ, the lung.
Dietary α-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets
TLDR
Results indicate that dietary supplementation with 1% AKG activates the mTOR signaling, alleviates the mucosal damage, and improves the absorptive function of the small intestine in LPS-challenged piglets.
Glutamine decreases inflammation in infant rat endotoxemia.
Effects of dietary glycyl-glutamine on growth performance, small intestinal integrity, and immune responses of weaning piglets challenged with lipopolysaccharide.
TLDR
In conclusion, considerable suppression of growth and immune function occurred in early weaning piglets challenged with LPS, and such depression could be alleviated by dietary Gly-Gln supplementation independent of the LPS challenge.
Dietary glutamine supplementation reduces cellular adhesion molecule expression and tissue myeloperoxidase activity in mice with gut-derived sepsis.
Arginyl-Glutamine Dipeptide or Docosahexaenoic Acid Attenuates Hyperoxia-induced Small Intestinal Injury in Neonatal Mice
  • N. Li, Liya Ma, +4 authors J. Neu
  • Biology, Medicine
    Journal of pediatric gastroenterology and nutrition
  • 2012
Background and Objective: Supplementation studies of glutamine, arginine, and docosahexaenoic acid (DHA) have established the safety of each of these nutrients in neonates; however, the potential for…
Glutamine downregulates TLR-2 and TLR-4 expression and protects intestinal tract in preterm neonatal rats with necrotizing enterocolitis.
Glutamine supplementation influences immune development in the newly weaned piglet.
Effects of dietary glutamine on adhesion molecule expression and oxidative stress in mice with streptozotocin-induced type 1 diabetes.
Protective effect of glutamine and arginine against soybean meal‐induced enteritis in the juvenile turbot (Scophthalmus maximus)
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