Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo.

Abstract

Glucose and glutamine are the two principal nutrients that cancer cells use to proliferate and survive. Many cancers show altered glucose metabolism, which constitutes the basis for in vivo positron emission tomography (PET) imaging with (18)F-fluorodeoxyglucose ((18)F-FDG). However, (18)F-FDG is ineffective in evaluating gliomas because of high background… (More)
DOI: 10.1126/scitranslmed.aaa1009

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