Glutamine and glutathione counteract the inhibitory effects of mediators of sepsis in neonatal hepatocytes.

@article{Babu2001GlutamineAG,
  title={Glutamine and glutathione counteract the inhibitory effects of mediators of sepsis in neonatal hepatocytes.},
  author={Ravi Babu and Simon Eaton and David Paul Drake and L. Spitz and Agostino Pierro},
  journal={Journal of pediatric surgery},
  year={2001},
  volume={36 2},
  pages={282-6}
}
BACKGROUND/PURPOSE Surgical neonates are at risk of sepsis-associated liver dysfunction. Hydrogen peroxide (H(2)O(2)) and nitric oxide (NO) are important mediators of sepsis, which impair neonatal hepatic metabolism. Glutamine has been shown to have beneficial effects on hepatocyte metabolism during neonatal sepsis. However, the molecular basis of these effects are unknown. The aim of this study was to test the hypotheses that (1) glutamine and its dipeptides counteract the inhibitory effect of… CONTINUE READING