Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells.

  title={Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells.},
  author={St{\'e}phanie Beutheu and Ibtissem Ghouzali and L. Galas and P. D{\'e}chelotte and M. Co{\"e}ffier},
  journal={Clinical nutrition},
  volume={32 5},
  • Stéphanie Beutheu, Ibtissem Ghouzali, +2 authors M. Coëffier
  • Published 2013
  • Biology, Medicine
  • Clinical nutrition
  • BACKGROUND & AIMS Chemotherapy induces an increase of intestinal permeability that is partially related to an alteration of tight junction proteins, occludin and zonula occludens-1 (ZO-1). Protective effects of glutamine on intestinal barrier function have been previously shown but the effects of other amino acids remained poorly documented. Thus, we aimed to evaluate the effects of nine amino acids on intestinal permeability during methotrexate (MTX) treatment in Caco-2 cells. METHODS Caco-2… CONTINUE READING
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