Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells.

@article{Beutheu2013GlutamineAA,
  title={Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells.},
  author={St{\'e}phanie Beutheu and Ibtissem Ghouzali and L. Galas and P. D{\'e}chelotte and M. Co{\"e}ffier},
  journal={Clinical nutrition},
  year={2013},
  volume={32 5},
  pages={
          863-9
        }
}
  • Stéphanie Beutheu, Ibtissem Ghouzali, +2 authors M. Coëffier
  • Published 2013
  • Biology, Medicine
  • Clinical nutrition
    • BACKGROUND & AIMS Chemotherapy induces an increase of intestinal permeability that is partially related to an alteration of tight junction proteins, occludin and zonula occludens-1 (ZO-1). Protective effects of glutamine on intestinal barrier function have been previously shown but the effects of other amino acids remained poorly documented. Thus, we aimed to evaluate the effects of nine amino acids on intestinal permeability during methotrexate (MTX) treatment in Caco-2 cells. METHODS Caco-2… CONTINUE READING
    View on PubMed
    doi.org
    53 Citations
    Highly Influential Citations
    2
    Background Citations
    17
    Methods Citations
    1
    Results Citations
    2
    53 Citations
    Citation Type

    Citation Type

    Yogurt inhibits intestinal barrier dysfunction in Caco-2 cells by increasing tight junctions.
    • 23
    Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome.
    • 26
    The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism.
    • Qingxue Fu, H. Wang, +5 authors Y. Xie
    • Chemistry, Medicine
    • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
    • 2015
    • 25
    Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions.
    • 22
    Protection against Gluten-mediated Tight Junction Injury with a NovelLignite Extract Supplement
    • 2
    • PDF
    Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats.
    • 50
    L-Glutamate Enhances Barrier and Antioxidative Functions in Intestinal Porcine Epithelial Cells.
    • 49
    • PDF
    Protective Effects of Lignite Extract Supplement on Intestinal Barrier Function in Glyphosate-Mediated Tight Junction Injury
    • 1
    • PDF
    Arginine affects growth and integrity of grass carp enterocytes by regulating TOR signaling pathway and tight junction proteins
    • 4
    • Highly Influenced
    Glutamine and the regulation of intestinal permeability: from bench to bedside
    • 28

    References

    SHOWING 1-10 OF 36 REFERENCES
    Glutamine regulates Caco-2 cell tight junction proteins.
    • 132
    • PDF
    Methotrexate Modulates Tight Junctions Through NF-&kgr;B, MEK, and JNK Pathways
    • 61
    Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats
    • 51
    Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity.
    • 34
    L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer.
    • 102
    • PDF
    Glutamine preserves protein synthesis and paracellular permeability in Caco-2 cells submitted to "luminal fasting".
    • 72
    Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function.
    • 25
    • PDF
    Effects of essential amino acids or glutamine deprivation on intestinal permeability and protein synthesis in HCT-8 cells: involvement of GCN2 and mTOR pathways
    • 21
    Ethanol modulation of intestinal epithelial tight junction barrier.
    • 214
    Glutamine reduces phorbol-12,13-dibutyrate-induced macromolecular hyperpermeability in HT-29Cl.19A intestinal cells.
    • 27