Glutamine: A novel approach to chemotherapy-induced toxicity

@article{Gaurav2012GlutamineAN,
  title={Glutamine: A novel approach to chemotherapy-induced toxicity},
  author={Kumar Gaurav and Ruchi Goel and Mridula Shukla and Manoj Pandey},
  journal={Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical \& Paediatric Oncology},
  year={2012},
  volume={33},
  pages={13 - 20}
}
  • K. Gaurav, R. Goel, +1 author M. Pandey
  • Published 2012
  • Medicine
  • Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology
Treatment of cancer is associated with short- and long-term side-effects. Cancer produces a state of glutamine deficiency, which is further aggravated by toxic effects of chemotherapeutic agents leading to increased tolerance of tumor to chemotherapy as well as reduced tolerance of normal tissues to the side-effects of chemotherapy. This article reviews the possible role of glutamine supplementation in reducing the serious adverse events in patients treated with anticancer drugs. The literature… 
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Parenteral glutamine appears to be feasible and safe to prevent oral mucositis in patients receiving HDMTX, and no severe adverse effects associated with glutamine administration were noted.
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The safety of two nutritional drinks (plus placebo) were determined, and then potential gut protection in tumor-bearing rats in a model of methotrexate-induced mucositis was investigated, which showed no significant influence of test diet on bodyweight, organ weight, tumor burden or biochemical parameters.
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Gln-enriched nutritional therapy can effectively improve the systemic nutritional status of children with leukemia, improve immune function and reduce the number of natural killer cells in peripheral blood of the two groups.
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