Glutamic acid 204 is the terminal proton release group at the extracellular surface of bacteriorhodopsin.

@article{Brown1995GlutamicA2,
  title={Glutamic acid 204 is the terminal proton release group at the extracellular surface of bacteriorhodopsin.},
  author={Leonid S Brown and Junzo Sasaki and Hideki Kandori and Akio Maeda and Richard Needleman and Janos K. Lanyi},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 45},
  pages={
          27122-6
        }
}
We have measured proton release into the medium after proton transfer from the retinal Schiff base to Asp85 in the photocycle and the C = O stretch bands of carboxylic acids in wild type bacteriorhodopsin and the E204Q and E204D mutants. In E204Q, but not in E204D, the normal proton release is absent. Consistent with this, a negative band in the Fourier transform infrared difference spectra at 1700 cm-1 in the wild type, which we now attribute to depletion of the protonated E204, is also absent… CONTINUE READING

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