Glutamic acid – amino acid, neurotransmitter, and drug – is responsible for protein synthesis rhythm in hepatocyte populations in vitro and in vivo

Abstract

Primary cultures of rat hepatocytes were studied in serum-free media. Ultradian protein synthesis rhythm was used as a marker of cell synchronization in the population. Addition of glutamic acid (0.2 mg/ml) to the medium of nonsynchronous sparse cultures resulted in detection of a common protein synthesis rhythm, hence in synchronization of the cells. The… (More)
DOI: 10.1134/S0006297916080101

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