Glutamic Acid Decarboxylase 65: A Link Between GABAergic Synaptic Plasticity in the Lateral Amygdala and Conditioned Fear Generalization

@article{Lange2014GlutamicAD,
  title={Glutamic Acid Decarboxylase 65: A Link Between GABAergic Synaptic Plasticity in the Lateral Amygdala and Conditioned Fear Generalization},
  author={Maren Denise Lange and Kay J{\"u}ngling and Linda Paulukat and Marc Vieler and Stefano Gaburro and Ludmila Sosulina and Peter Blaesse and Hari Kishore Sreepathi and Francesco Ferraguti and H. Pape},
  journal={Neuropsychopharmacology},
  year={2014},
  volume={39},
  pages={2211-2220}
}
An imbalance of the gamma-aminobutyric acid (GABA) system is considered a major neurobiological pathomechanism of anxiety, and the amygdala is a key brain region involved. Reduced GABA levels have been found in anxiety patients, and genetic variations of glutamic acid decarboxylase (GAD), the rate-limiting enzyme of GABA synthesis, have been associated with anxiety phenotypes in both humans and mice. These findings prompted us to hypothesize that a deficiency of GAD65, the GAD isoform… CONTINUE READING
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