Glutamatergic theories of schizophrenia.

@article{Javitt2010GlutamatergicTO,
  title={Glutamatergic theories of schizophrenia.},
  author={D. C. Javitt},
  journal={The Israel journal of psychiatry and related sciences},
  year={2010},
  volume={47 1},
  pages={4-16}
}
  • D. C. Javitt
  • Published 2010 in
    The Israel journal of psychiatry and related…
Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide. Traditional models of schizophrenia have emphasized dopaminergic dysfunction. Over the last 20 years, however, limitations of the dopamine model have become increasingly apparent, necessitating development of alternative models. Glutamatergic models are based upon the observation that the psychotomimetic agents such as phencyclidine (PCP) and ketamine induce psychotic symptoms and neurocognitive… CONTINUE READING
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