Glutamatergic theories of schizophrenia.

  title={Glutamatergic theories of schizophrenia.},
  author={D. C. Javitt},
  journal={The Israel journal of psychiatry and related sciences},
  volume={47 1},
  • D. C. Javitt
  • Published 2010 in
    The Israel journal of psychiatry and related…
Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide. Traditional models of schizophrenia have emphasized dopaminergic dysfunction. Over the last 20 years, however, limitations of the dopamine model have become increasingly apparent, necessitating development of alternative models. Glutamatergic models are based upon the observation that the psychotomimetic agents such as phencyclidine (PCP) and ketamine induce psychotic symptoms and neurocognitive… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 111 extracted citations


Publications referenced by this paper.
Showing 1-10 of 112 references

Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidine

  • RT Keeffe, K Lifshitz, C Schroeder, DC. Javitt
  • Psychopharmacology (Berl)
  • 2007

Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia

  • GA Jones
  • Brain Res
  • 2007

Similar Papers

Loading similar papers…