Glutamatergic synaptic currents of nigral dopaminergic neurons follow a postnatal developmental sequence

@inproceedings{Pearlstein2015GlutamatergicSC,
  title={Glutamatergic synaptic currents of nigral dopaminergic neurons follow a postnatal developmental sequence},
  author={Edouard Pearlstein and Laurie-Anne Gouty-Colomer and François J. Michel and Robin Cloarec and C. Featherstone Hammond},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
The spontaneous activity pattern of adult dopaminergic (DA) neurons of the substantia nigra pars compacta (SNc) results from interactions between intrinsic membrane conductances and afferent inputs. In adult SNc DA neurons, low-frequency tonic background activity is generated by intrinsic pacemaker mechanisms, whereas burst generation depends on intact synaptic inputs in particular the glutamatergic ones. Tonic DA release in the striatum during pacemaking is required to maintain motor activity… CONTINUE READING
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