Glutamatergic substrates of drug addiction and alcoholism.

  title={Glutamatergic substrates of drug addiction and alcoholism.},
  author={Justin T Gass and M Foster Olive},
  journal={Biochemical pharmacology},
  volume={75 1},
The past two decades have witnessed a dramatic accumulation of evidence indicating that the excitatory amino acid glutamate plays an important role in drug addiction and alcoholism. The purpose of this review is to summarize findings on glutamatergic substrates of addiction, surveying data from both human and animal studies. The effects of various drugs of abuse on glutamatergic neurotransmission are discussed, as are the effects of pharmacological or genetic manipulation of various components… CONTINUE READING
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