Glutamatergic regulation of gonadotropin releasing hormone mRNA levels during development in the mouse.

@article{Ford2000GlutamatergicRO,
  title={Glutamatergic regulation of gonadotropin releasing hormone mRNA levels during development in the mouse.},
  author={Heide Ford and Francis J P Ebling},
  journal={Journal of neuroendocrinology},
  year={2000},
  volume={12 10},
  pages={1027-33}
}
The aims of these studies were to investigate the time course of the increase in gonadotropin releasing hormone (GnRH) mRNA levels during sexual development in the mouse, and to test the hypothesis that the neurotransmitter glutamate regulates the GnRH secretory system via actions at the level of GnRH gene expression. GnRH mRNA abundance was estimated by measuring silver grains generated by in situ hybridization of an 35S-labelled oligonucleotide probe. There was a significant increase in GnRH… CONTINUE READING