Glutamatergic neurotransmission in the prefrontal cortex mediates the suppressive effect of intra-prelimbic cortical infusion of BDNF on cocaine-seeking.

Abstract

Cocaine self-administration induces dysfunctional neuroadaptations in the prefrontal cortex that underlie relapse to cocaine-seeking. Cocaine self-administration disturbs glutamatergic transmission in the nucleus accumbens that is prevented by infusion of brain-derived neurotrophic factor (BDNF) into the prelimbic area of the prefrontal cortex. Intra… (More)
DOI: 10.1016/j.euroneuro.2016.10.002

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@article{Go2016GlutamatergicNI, title={Glutamatergic neurotransmission in the prefrontal cortex mediates the suppressive effect of intra-prelimbic cortical infusion of BDNF on cocaine-seeking.}, author={Bok Soon Go and Sarah M Barry and Jacqueline F McGinty}, journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, year={2016}, volume={26 12}, pages={1989-1999} }