Glutamatergic modulation of auditory information processing in the human brain.

@article{GunduzBruce2012GlutamatergicMO,
  title={Glutamatergic modulation of auditory information processing in the human brain.},
  author={Handan Gunduz-Bruce and Robert M. G. Reinhart and Brian J. Roach and Ralitza Gueorguieva and Stephen Oliver and Deepak Cyril D'souza and Judith M. Ford and John H. Krystal and Daniel H. Mathalon},
  journal={Biological psychiatry},
  year={2012},
  volume={71 11},
  pages={969-77}
}
BACKGROUND Auditory mismatch negativity (MMN) and P300 event-related potentials (ERPs) are reduced in schizophrenia patients and healthy volunteers administered the N-methyl-D-aspartate glutamate receptor antagonist, ketamine. In rodents, N-acetylcysteine (NAC), a stimulator of the cystine-glutamate exchanger, attenuates the cognitive and behavioral effects of N-methyl-D-aspartate receptor antagonists. On the basis of these findings, we tested whether NAC would reduce ketamine effects on… CONTINUE READING
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