Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

@article{Refojo2011GlutamatergicAD,
  title={Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.},
  author={Damian Refojo and Martin C. Schweizer and Claudia Kuehne and Stefanie Ehrenberg and Christoph K. Thoeringer and Annette M. Vogl and Nina Dedic and Marion Schumacher and Gregor von Wolff and Charilaos Avrabos and Chadi Touma and David Engblom and G{\"u}nther Sch{\"u}tz and Klaus-Armin Nave and Matthias Eder and Carsten T. Wotjak and Inge Sillaber and Florian Holsboer and Wolfgang Wurst and Jan M. Deussing},
  journal={Science},
  year={2011},
  volume={333 6051},
  pages={
          1903-7
        }
}
  • Damian Refojo, Martin C. Schweizer, +17 authors Jan M. Deussing
  • Published in Science 2011
  • DOI:10.1126/science.1202107
The corticotropin-releasing hormone receptor 1 (CRHR1) critically controls behavioral adaptation to stress and is causally linked to emotional disorders. Using neurochemical and genetic tools, we determined that CRHR1 is expressed in forebrain glutamatergic and γ-aminobutyric acid-containing (GABAergic) neurons as well as in midbrain dopaminergic neurons. Via specific CRHR1 deletions in glutamatergic, GABAergic, dopaminergic, and serotonergic cells, we found that the lack of CRHR1 in forebrain… CONTINUE READING

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